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Escherichia coli adenylate cyclase homepage

A monthly updated publication of the Mednansky Institute
Author: Martine Crasnier-Mednansky, Ph.D., D.Sc.
 Copyright © 2004-2008, Mednansky Institute, Inc. 
Contact: ecach@minst.org

"The crucial experiment is the crucial stage of research… The crucial experiment appears like a simple scheme, but it is the most delicate operation and the most difficult to set up." [Etienne Wolff, 1904-1996]

This online review is intended for higher education and researchers in the field.  It is supported by grant A-2006-00376 from the "Reuben H. Fleet Foundation Fund" at "The San Diego Foundation".

TABLE of CONTENTS

Introduction†

Chapter I
In vivo regulation of adenylate cyclase

Chapter II
The glucose specific IIA protein

Chapter III
The fructose phosphotransferase system

Chapter IV
Glucose 6-phosphate transport

Chapter V
The catalytic and regulatory domain of adenylate cyclase

Chapter VI
Characterization of adenylate cyclase mutants

Chapter VII
Purification of adenylate cyclase

Commentaries

Welcome to a new cousin!


†Updated
Last update: Friday, April 25, 2008

This publication is updated on or around the 25th of each month.  It contains hyperlinks to external sources that may have intermittent problems and may not be available.  External links will open in a new browser window.  Ecach uses EcoCyc as a source for the description of Escherichia coli K12 genes and RCSB Protein Data Bank for biological macromolecular structures.  Some readers will find it helpful to read chapters consecutively as there is a logic in their order.

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Cyclic AMP in Escherichia coli
including:
-The CAP family of proteins
-The translation of adenylate cyclase mRNA
Effect of the carbon source and introduction of the phosphotransferase system (PTS)
including:
-A color-coded version of the PTS
Regulation of adenylate cyclase and inducer exclusion
including:
-The MalX protein of Escherichia coli
-The CAP-dependent activation of adenylate cyclase
FruR-mediated regulation of adenylate cyclase
including:
The fructose repressor of Escherichia coli
Effect on adenylate cyclase
A molecular model of interaction between domains
Identification of essential residues for activation
In vitro studies and enzymatic properties
"False facts, false views or both?"
Posted on September 24, 2005



Transmission electron microscope picture of E. coli with flagella and fimbriae [3,515 times magnification]
Copyright Dennis Kunkel Microscopy, Inc.