Martine Crasnier-Mednansky holds a Ph.D. and a D.Sc. in biochemistry from the University of Aix-Marseilles, France. The degree of Doctor of Science (D.Sc.) is the most advanced degree conferred by universities in recognition of published work which results from research, constitutes a significant and original contribution to science, and has established a researcher's authoritative standing in a subject of research.
From 1980 to 1996, she was employed by the French National Center for Scientific Research (CNRS) initially as "Attaché de Recherche" (Attached to Research). In 1984, she was promoted to "Chargé de Recherche" (In Charge of Research), and in 1988 "Chargé de Recherche de Première Classe" (In Charge of Research, First Class). From 1980 to 1985, she conducted research at the "Centre de Biochimie et de Biologie Moléculaire", CNRS, Marseilles with enzymologist Professor Jacques Ricard, Professor Emeritus University Paris VII, formerly director of the Jacques Monod Institute, Paris. Dr. Crasnier-Mednansky's academic record from 1980 to 1985 is best illustrated by a list of selected publications. Click anywhere within the paragraph. In 1985, she moved to the University of Birmingham, Birmingham, England where she conducted research as an "Honorary Research Scientist" (on sabbatical leave from the CNRS) to study the physicochemical interactions between the muscle proteins actin and myosin. In 1987, she joined the University of Massachusetts Medical Center, Worcester, Massachusetts, USA (on leave of absence from the CNRS) to develop molecular biology techniques for protein expression. She returned to France in 1988 to develop a new research program at the "Pasteur Institute" in Paris where she conducted and directed research for seven years. The study of Escherichia coli adenylate cyclase became her primary interest of research. In 1995, she left the Pasteur Institute (on sabbatical leave from the CNRS) to join the University of California at San Diego (La Jolla, CA, USA) where she continued her research on Escherichia coli adenylate cyclase. In 1997, she was invited to work at NIH, the National Institute of Health (Bethesda, MD, USA) as a "Senior Research Scientist" to pursue her studies on E. coli adenylate cyclase. A list of publications related to E. coli adenylate cyclase illustrates Dr. Crasnier-Mednansky's research and collaborations. Click anywhere within the paragraph. Besides research, Dr. Mednansky is dedicated to education, particularly through her devotion towards students for their training and integration in the laboratory. She was described by one of her graduate students in the following terms: "…she has taught me to appreciate the process of finding scientific results, from creating lab environment to conducting the science itself. She has shown me first-hand that this process is intimately related to the integrity of such findings". Dr. Mednansky has also taught several classes for graduate and undergraduate students. After her departure from NIH, Dr. Mednansky has undertaken the chore of establishing the Mednansky Institute and is presently involved in this pursuit. When asked what it will take to bring the institute into the future, she quotes the Red Queen from Lewis Carroll's Through the Looking Glass: "…it takes all the running you can do to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that!". Dr. Mednansky is a full member of the American Society for Microbiology since 1993, and as such ascribes to that Society's code of ethics.
|

1- M. Crasnier, G. Noat and J. Ricard
Purification and Molecular Properties of Acid Phosphatase from Sycamore Cell Walls, Plant, Cell and Environment, 1980, Vol. 3, p. 217
2- G. Noat, M. Crasnier and J. Ricard
Ionic Control of Acid Phosphatase Activity in Plant Cell Walls, Plant, Cell and Environment, 1980, Vol. 3, p. 225
3- J. Ricard, G. Noat, M. Crasnier and D. Job [Medline]
Ionic Control of Immobilized Enzymes. Kinetics of acid phosphatase bound to plant cell walls, Biochemical Journal, 1981, vol. 195, p. 357
4- M. Crasnier, J. Ricard and G. Noat [CrossRef]
pH Regulation of Acid Phosphatase of Plant Cell Walls, FEBS Letters, 1982, vol. 144, p. 309
5- J. Ricard, G. Noat and M. Crasnier
Electrostatic Repulsion Effects and the Dynamic Behavior of Enzymes Embedded in Biological Polyelectrolytes, In Dynamics of Biochemical Systems, Ricard and Cornish-Bowden Eds., 1984, p. 133
6- J. Ricard and M. Crasnier [Medline]
pH Modulation of the Transient State Kinetics of Enzymes, I-Simple Theoretical Models, Biophysical Chemistry, 1984, vol. 19, p. 85
7- M. Crasnier and J. Ricard [CrossRef]
pH Modulation of the Transient State Kinetics of Enzymes, II-Transient State Kinetics of Plant Cell Wall Acid Phosphatase, Biophysical Chemistry, 1984, vol. 19, p. 93
8- M. Crasnier and R. Giordani [CrossRef]
Elution of Acid Phosphatase from Sycamore Cell Walls, Plant Science Letters, 1985, vol. 40, p. 35
9- M. Crasnier, A.M. Moustacas and J. Ricard [Medline]
Electrostatic Effects and Calcium Ion Concentration as Modulators of Acid Phosphatase Bound to Plant Cell Walls, European Journal of Biochemistry, 1985, vol. 151, p.187
10- A. M. Moustacas, J. Nari, G. Diamantidis, G. Noat, M. Crasnier, M. Borel and J. Ricard [Medline]
Electrostatic Effects and the Dynamics of Enzyme Reactions at the Surface of Plant Cell, European Journal of Biochemistry, 1986, vol. 155, p. 191
1- M. Crasnier and A. Danchin [Medline]
Characterization of Escherichia coli Adenylate Cyclase Mutants with Modified Regulation, Journal of General Microbiology, 1990, vol. 136, p. 1825
2- A. Beuve, B. Boesten, M. Crasnier, A. Danchin and F. O’Gara [Medline]
Rhizobium meliloti Adenylate Cyclase is Related to Eucaryotic Adenylate and Guanylate Cyclases, Journal of Bacteriology, 1990, vol. 172, p. 2614
3- M. Mock, M. Crasnier, E. Duflot , V. Dumay and A. Danchin [Medline]
Structural and Functional Relationships between Pasteurella multocida and Enterobacterial Adenylate Cyclases, Journal of Bacteriology, 1991, vol. 173, p. 6265
4- F. Escande and M. Crasnier [Medline]
Detection of an Adenylate Cyclase Gene in Pasteurella Species, Zentralblatt für Bakteriologie, 1993, vol. 279, p. 45
5- V. Dumay and M. Crasnier [Medline]
Role of the Phosphotransferase system in Escherichia coli strains deficient in hexose phosphate transport, FEMS Microbiology Letters, 1994, vol. 116, p. 209
6- M. Crasnier, V. Dumay and A. Danchin [Medline]
The catalytic domain of Escherichia coli adenylate cyclase as revealed by deletion analysis of the cya gene, Molecular and General Genetics, 1994, vol. 243, p. 409
7- V. Dumay, A. Danchin and M. Crasnier [Medline]
Regulation of Escherichia coli adenylate cyclase during hexose phosphate transport, Microbiology, 1996, vol. 142, p. 575
8- M. Crasnier [Medline]
Cyclic AMP and Catabolite Repression, Research in Microbiology, 1996, vol. 147, p. 479
9- M. H. Saier, Jr. and M. Crasnier [Medline]
Inducer exclusion and the regulation of sugar transport, Research in Microbiology, 1996, vol. 147, p. 482
10- M. Crasnier-Mednansky, M. C. Park , W. K. Studley and M. H. Saier, Jr. [Microbiology]
Cra-mediated regulation of Escherichia coli adenylate cyclase, Microbiology, 1997, vol. 143, p. 785
11- M. Crasnier-Mednansky [MIeJ]
Diauxie revisited: the case of fructose, MIeJ, 1998
12- M. Santana and M. Crasnier-Mednansky [FEMS Microbiology Letters]
The adaptive genome of Desulfovibrio vulgaris Hildenborough, FEMS Microbiology Letters, 2006, vol. 260, p. 127